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Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease.

作者信息

Altimiras Francisco, Uszczynska-Ratajczak Barbara, Camara Francisco, Vlasova Anna, Palumbo Emilio, Newhouse Stephen, Deacon Robert M J, Farias Leandro A E, Hurley Michael J, Loyola David E, Vásquez Rodrigo A, Dobson Richard, Guigó Roderic, Cogram Patricia

机构信息

Faculty of Engineering and Sciences, Universidad Adolfo IbañezSantiago, Chile; Telefonica Research and DevelopmentSantiago, Chile.

Centre for Genomic Regulation, Barcelona Institute of Science and TechnologyBarcelona, Spain; Universitat Pompeu FabraBarcelona, Spain.

出版信息

Front Aging Neurosci. 2017 Mar 20;9:64. doi: 10.3389/fnagi.2017.00064. eCollection 2017.

DOI:10.3389/fnagi.2017.00064
PMID:28373841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5357652/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7625/5357652/c6746fbe58f7/fnagi-09-00064-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7625/5357652/c6746fbe58f7/fnagi-09-00064-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7625/5357652/c6746fbe58f7/fnagi-09-00064-g0001.jpg

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Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.

本文引用的文献

1
Masculinized females produce heavier offspring in a group living rodent.在群居啮齿动物中，雄性化的雌性会产出体重更重的后代。
J Anim Ecol. 2016 Nov;85(6):1552-1562. doi: 10.1111/1365-2656.12588. Epub 2016 Sep 26.
2
Genetic variants associated with neurodegenerative Alzheimer disease in natural models.自然模型中与神经退行性阿尔茨海默病相关的基因变异。
Biol Res. 2016 Feb 26;49:14. doi: 10.1186/s40659-016-0072-9.
3
Retinal aging in the diurnal Chilean rodent (Octodon degus): histological, ultrastructural and neurochemical alterations of the vertical information processing pathway.
英国生物库中阿尔茨海默病多基因风险极值的全基因组关联分析。
Sci Rep. 2022 May 19;12(1):8404. doi: 10.1038/s41598-022-12391-2.
4
Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer's disease.健康八齿鼠（一种散发性阿尔茨海默病的自然模型）海马体中的空间图谱和振荡。
Sci Rep. 2022 May 5;12(1):7350. doi: 10.1038/s41598-022-11153-4.
5
Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus.衰老八齿鼠视网膜中突触和神经化学重塑的证据。
Front Neurosci. 2020 Mar 18;14:161. doi: 10.3389/fnins.2020.00161. eCollection 2020.
6
Visual Features in Alzheimer's Disease: From Basic Mechanisms to Clinical Overview.阿尔茨海默病的视觉特征：从基础机制到临床概述。
Neural Plast. 2018 Oct 14;2018:2941783. doi: 10.1155/2018/2941783. eCollection 2018.
智利昼行性啮齿动物（八齿鼠）的视网膜老化：垂直信息处理通路的组织学、超微结构和神经化学改变
Front Cell Neurosci. 2015 Apr 21;9:126. doi: 10.3389/fncel.2015.00126. eCollection 2015.
4
Rodent models of neuroinflammation for Alzheimer's disease.用于阿尔茨海默病的神经炎症啮齿动物模型。
J Neuroinflammation. 2015 Apr 17;12:74. doi: 10.1186/s12974-015-0291-y.
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Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation.八齿鼠的自然性类阿尔茨海默病神经病理学：掘洞行为受损与神经炎症
Curr Alzheimer Res. 2015;12(4):314-22. doi: 10.2174/1567205012666150324181652.
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Curr Opin Psychiatry. 2015 Mar;28(2):155-64. doi: 10.1097/YCO.0000000000000137.
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Neuropharmacology. 2015 Sep;96(Pt B):255-62. doi: 10.1016/j.neuropharm.2014.11.018. Epub 2014 Dec 13.
8
Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease.智利啮齿动物八齿鼠大脑中神经病理学标志物的年龄进展，阿尔茨海默病的天然模型
Brain Pathol. 2015 Nov;25(6):679-91. doi: 10.1111/bpa.12226. Epub 2015 Feb 10.
9
Modulation of inflammation in transgenic models of Alzheimer's disease.阿尔茨海默病转基因模型中的炎症调节。
J Neuroinflammation. 2014 Feb 3;11:25. doi: 10.1186/1742-2094-11-25.
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We can treat Alzheimer's disease successfully in mice but not in men: failure in translation? A perspective.我们可以成功治疗老鼠的阿尔茨海默病，但不能治疗人类的：是转化失败了吗？一种观点。
Neurodegener Dis. 2014;13(2-3):147-50. doi: 10.1159/000357568. Epub 2014 Jan 7.