Komarnicki M, Kaźmierczak M, Krupa D
Kliniki Hematologii Instytutu Chorób Wewnetrznych AM.
Pol Tyg Lek. 1993;48(5-6):103-4.
An effect of a standard heparin preparation on the interaction between blood platelets and collagen has been investigated. The experiments have shown, that the addition of heparin in the concentration of 0.3; 0.6 or 0.9 IU/mL did not change the interaction between blood platelets and collagen. Such interaction increased, when heparin concentration was 1,2 IU/mL, and remained unchanged despite the further increase in heparin concentration. The authors suggest that such a course of this interaction results from the stimulating action of heparin added in adequate concentration on protein release from platelet alpha granulations--which bound GP II b/III a complex with collagen.
研究了一种标准肝素制剂对血小板与胶原蛋白之间相互作用的影响。实验表明，添加浓度为0.3；0.6或0.9 IU/mL的肝素不会改变血小板与胶原蛋白之间的相互作用。当肝素浓度为1.2 IU/mL时，这种相互作用增强，并且尽管肝素浓度进一步增加，其仍保持不变。作者认为，这种相互作用过程是由于添加适当浓度的肝素对血小板α颗粒释放蛋白质具有刺激作用——该蛋白质将GP II b/III a复合物与胶原蛋白结合。
