Lindsay R M, Rourke J, Reid B, Friesen M, Linton A L, Courtney J, Gilchrist T
Trans Am Soc Artif Intern Organs. 1976;22:292-6.
These studies clearly indicate that heparin has 2 antagonistic effects in this platelet-foreign surface interaction; it acts directly on platelets to increase retention, while acting on the foreign surface to reduce platelet retention, perhaps by competing for cationic sites. This study also suggests that it is unlikely that heparin bonding confers reduced surface thrombogenicity by virtue of the ability to leach off that surface and that further studies in heparin bonding or other surface modification should consider the antiplatelet effect which can easily be studied in vitro.
这些研究清楚地表明，肝素在这种血小板与异物表面的相互作用中具有两种拮抗作用；它直接作用于血小板以增加黏附，同时作用于异物表面以减少血小板黏附，可能是通过竞争阳离子位点来实现的。这项研究还表明，肝素结合不太可能凭借从该表面浸出的能力而赋予表面血栓形成性降低，并且在肝素结合或其他表面修饰方面的进一步研究应考虑到这种抗血小板作用，而这种作用很容易在体外进行研究。
