Michel R G, Johnson K A, Patterson C N
Arch Otolaryngol. 1977 Feb;103(2):94-7. doi: 10.1001/archotol.1977.00780190074008.
Twenty mentally retarded patients with a considerable drooling problem underwent transtympanic sectioning of selected preganglionic parasympathetic nerve fibers to the major salivary glands. Following surgery, cessation of trouble-some sialorrhea occurred in 15 to 20 patients; but by six months postoperatively, only ten patients remained controlled. The best results obtained were in a subgroup of five patients who underwent bilateral Jacobson nerve and chorda tympani nerve section. In four of these patients, sialorrhea was controlled after a minimum follow-up of two years. Parasympathetic denervation of the major salivary glands via a transtympanic approach is offered as a primary modality of therapy in those mentally retarded patients judged to have considerable sialorrhea. Sacrifice of both chorda tympani nerves appears to enhance the surgical results.
20名存在严重流涎问题的智障患者接受了经鼓室对支配主要唾液腺的节前副交感神经纤维进行的部分切断术。术后，15至20名患者烦人的流涎症状停止；但术后6个月时，仅有10名患者的症状得到控制。效果最佳的是接受双侧鼓索神经和鼓室神经切断术的5名患者亚组。在这些患者中，有4名在至少随访两年后流涎得到控制。对于那些被判定存在严重流涎的智障患者，经鼓室途径对主要唾液腺进行副交感神经去神经支配被作为一种主要治疗方式。切断双侧鼓索神经似乎能提高手术效果。
