Snow B J, Tooyama I, McGeer E G, Yamada T, Calne D B, Takahashi H, Kimura H
Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.
Ann Neurol. 1993 Sep;34(3):324-30. doi: 10.1002/ana.410340304.
Postmortem counts of dopaminergic cell densities in the substantia nigra (5 subjects) and striatal levels of dopamine (DA) and its metabolites (6 subjects) were determined on 1 parkinsonian (PD), 3 progressive supranuclear palsy (PSP), 1 amyotrophic lateral sclerosis, and 1 Alzheimer's case who had been positron emission tomography scanned with 6-[18F]fluorodopa during life. [18F]Fluorodopa uptake rate constants, which presumably depend on the number of functioning striatal DA terminals, were strictly proportional to cell densities (significant correlation with zero intercept) and also correlated significantly with striatal DA levels but with an intercept indicating greater losses of DA than of terminals in PSP and PD. Postmortem data on 6 PD, 1 PSP, and 9 neuronally normal controls substantiated the significant correlation between cell counts and DA levels, with the latter being the more depressed in pathological cases.
对1例帕金森病（PD）患者、3例进行性核上性麻痹（PSP）患者、1例肌萎缩侧索硬化患者和1例阿尔茨海默病患者在生前进行了正电子发射断层扫描，扫描时使用了6-[18F]氟多巴，测定了他们死后黑质中多巴胺能细胞密度（5例受试者）以及纹状体中多巴胺（DA）及其代谢产物水平（6例受试者）。[18F]氟多巴摄取速率常数可能取决于功能性纹状体DA终末的数量，它与细胞密度严格成正比（与零截距有显著相关性），并且与纹状体DA水平也显著相关，但截距表明在PSP和PD中DA的损失比终末的损失更大。对6例PD患者、1例PSP患者和9例神经正常对照的尸检数据证实了细胞计数与DA水平之间的显著相关性，在病理情况下后者的降低更为明显。
