Wu W, Cook M E, Chu Q, Smalley E B
Department of Poultry Science, University of Wisconsin, Madison 53706.
Avian Dis. 1993 Apr-Jun;37(2):302-9.
Chicks were fed for 3 weeks a practical broiler starter diet amended with fusarochromanone (FC), a mycotoxin. In Hubbard broiler chicks, the highest test dose of FC (75 ppm) suppressed body weight by 33% and humoral response to sheep erythrocytes by 34% to 50%, and increased the incidence of tibial dyschondroplasia (TD) to 100%. The intermediate dose (35 ppm) significantly increased the incidence of TD in both types of broiler chicks (Hubbard and Indian River), but its effect on humoral response to sheep erythrocytes was not consistent across several experiments. A minimum dietary concentration greater than 20 ppm was required to significantly increase the incidence of TD. Excessive dietary copper or zinc (200 ppm) alleviated the effect of FC on TD. However, activities of copper-dependent ceruloplasmin and superoxide dismutase was not affected by FC. Cartilage mineral profiles in FC- or Thiram-induced TD differed from that of 1-day-old hypertrophic embryonic cartilage core (less K and Mn). FC did not induce TD in leghorn chicks.
给雏鸡喂食添加了霉菌毒素镰孢色原酮（FC）的实用肉仔鸡育雏期日粮3周。在哈伯德肉仔鸡雏鸡中，最高测试剂量的FC（75 ppm）使体重降低了33%，对绵羊红细胞的体液反应降低了34%至50%，并使胫骨软骨发育不良（TD）的发生率增加到100%。中间剂量（35 ppm）显著增加了两种肉仔鸡雏鸡（哈伯德和印第安河）的TD发生率，但在几个实验中，其对绵羊红细胞体液反应的影响并不一致。日粮中FC浓度至少大于20 ppm才能显著增加TD的发生率。过量的日粮铜或锌（200 ppm）可减轻FC对TD的影响。然而，铜依赖性铜蓝蛋白和超氧化物歧化酶的活性不受FC影响。FC或福美双诱导的TD中的软骨矿物质分布与1日龄肥大胚胎软骨核心的不同（钾和锰含量较低）。FC未在来航鸡雏鸡中诱导TD。
