兔γ-前速激肽原I cDNA的核苷酸序列

Nucleotide sequence of the rabbit gamma-preprotachykinin I cDNA.

作者信息

Mägert H J, Heitland A, Rose M, Forssmann W G

机构信息

Lower Saxony Institute for Peptide-Research, Hannover, Germany.

出版信息

Biochem Biophys Res Commun. 1993 Aug 31;195(1):128-31. doi: 10.1006/bbrc.1993.2019.

DOI:10.1006/bbrc.1993.2019

Abstract

We succeeded in amplifying tachykinin I specific cDNAs from cerebral tissue of guinea pig, rabbit, rat, hamster, trout and tupaia in the expected size range of 820-980 bp. The amplified 859 bp rabbit gamma-preprotachykinin I cDNA was sequenced and consisted of the whole 345 bp gamma-PPT I coding sequence including the substance P and neurokinin A coding regions and a 505 bp large 3'-nontranslated region. Both, molecular weight and sequence comparison emphasizes the very high phylogenetic age of the preprotachykinin I gene.

摘要

我们成功地从豚鼠、兔子、大鼠、仓鼠、鳟鱼和树鼩的脑组织中扩增出大小在820 - 980 bp预期范围内的速激肽I特异性cDNA。对扩增出的859 bp兔γ-前速激肽I cDNA进行测序，其由整个345 bp的γ-PPT I编码序列组成，包括P物质和神经激肽A编码区以及一个505 bp的大3'非翻译区。分子量和序列比较均表明前速激肽I基因具有非常古老的系统发育年龄。

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