Defilippi C, Gomez E
Department of Physiology and Biophysics, Faculty of Medicine, University of Chile, Santiago.
Aliment Pharmacol Ther. 1993 Jun;7(3):327-30. doi: 10.1111/j.1365-2036.1993.tb00105.x.
The effects of trimebutine and domperidone, on the electrical and motor activity of the upper small bowel in dogs, were studied simultaneously by means of a suction electrode and a manometric catheter. Trimebutine, given during phases I and II of the migratory motor complex, was followed by a period of regular spike potentials and contractions; the increased motor activity was significantly greater when the drug was given during phase II. Domperidone, when injected in phase I, was followed by an irregular pattern of spike potentials and contractions of low amplitude. By contrast, activity was not augmented when the drug was given during phase II. We conclude that the effects of drugs, such as trimebutine and domperidone, on the canine small bowel are influenced by the phase of the migratory motor complex.
采用吸力电极和测压导管，同时研究了曲美布汀和多潘立酮对犬上小肠电活动和运动活性的影响。在移行性运动复合波的I期和II期给予曲美布汀后，出现一段规则的锋电位和收缩期；当在II期给予该药物时，运动活性的增加显著更大。在I期注射多潘立酮后，出现不规则的锋电位模式和低幅度收缩。相比之下，在II期给予该药物时活性并未增强。我们得出结论，曲美布汀和多潘立酮等药物对犬小肠的作用受移行性运动复合波阶段的影响。
