Zwissler B
Institut für Anästhesiologie der Ludwig-Maximilians-Universität München, Klinikum Grosshadern.
Infusionsther Transfusionsmed. 1993 Jun;20(3):116-20.
For long, the right ventricle (RV) has been looked upon as a passive conduit of blood, which does not contribute to overall myocardial performance. While this is true under physiological conditions, it has been recognized only recently that an intact RV may be of crucial importance for the maintenance of cardiocirculatory stability under pathophysiological circumstances, e.g. in patients with increased pulmonary vascular resistance (PVR). Hence, several techniques have been developed to monitor RV function in these patients. With respect to the monitoring of RV preload, the validity of parameters based on pressure measurement (e.g. central venous pressure, RV end-diastolic pressure) is limited by the nonlinearity of the RV pressure-volume relationship, changes of RV compliance (e.g. ischemia, drugs), and changes of intrathoracic pressure. The measurement of RV end-diastolic volume (RVEDV) or size provides a more accurate estimation of true RV fiber preload and is currently performed using the fast-response thermodilution technique. The exact quantitation of RV afterload requires the continuous assessment of RV pressure, geometry and wall thickness, which is not possible in the clinical setting. Mean pulmonary artery pressure (PAP and PVR may roughly reflect actual RV afterload under physiological conditions. However, neither PAP nor PVR take into account changes of afterload due to changes of RV size. With respect to RV contractility, none of the techniques presently available for its measurement is both valid and suitable as a tool for clinical monitoring.
长期以来,右心室一直被视为血液的被动通道,对整体心肌功能没有贡献。虽然在生理条件下确实如此,但直到最近才认识到,在病理生理情况下,如肺血管阻力(PVR)增加的患者中,完整的右心室对于维持心脏循环稳定性可能至关重要。因此,已经开发了几种技术来监测这些患者的右心室功能。关于右心室前负荷的监测,基于压力测量的参数(如中心静脉压、右心室舒张末期压力)的有效性受到右心室压力-容积关系的非线性、右心室顺应性的变化(如缺血、药物)以及胸内压变化的限制。右心室舒张末期容积(RVEDV)或大小的测量可以更准确地估计真正的右心室纤维前负荷,目前使用快速响应热稀释技术进行测量。右心室后负荷的精确量化需要持续评估右心室压力、几何形状和壁厚,这在临床环境中是不可能的。平均肺动脉压(PAP)和PVR在生理条件下可能大致反映实际的右心室后负荷。然而,PAP和PVR都没有考虑到由于右心室大小变化引起的后负荷变化。关于右心室收缩力,目前可用的测量技术都既无效也不适合作为临床监测工具。