Walden J, Altrup U, Reith H, Speckmann E J
Psychiatrische Klinik, Universität Freiburg, Germany.
Eur Neuropsychopharmacol. 1993 Jun;3(2):137-41. doi: 10.1016/0924-977x(93)90265-n.
The effects of valproate sodium (VPA) on potassium currents were tested in identified neurons of the snail Helix pomatia. VPA was extracellularly and intracellularly applied. VPA (i) had no effects on the current-voltage relation of the early potassium outward current (IA), (ii) shifted the steady state inactivation function of IA to more positive potentials, (iii) increased the amplitude of the late potassium outward currents. It is suggested that the extrasynaptic effects on potassium currents markedly contribute to the antiepileptic and antimanic effects of VPA.
在鉴定出的苹果蜗牛神经元中测试了丙戊酸钠（VPA）对钾电流的影响。VPA通过细胞外和细胞内给药。VPA：（i）对早期钾外向电流（IA）的电流-电压关系没有影响；（ii）将IA的稳态失活功能向更正电位移动；（iii）增加了晚期钾外向电流的幅度。提示VPA对钾电流的突触外作用显著促成了其抗癫痫和抗躁狂作用。
