评估促甲状腺激素（TSH）和催乳素对促甲状腺激素释放激素（TRH）的反应，以此作为电休克疗法（ECT）治疗抑郁症疗效的预测指标。

Evaluation of TSH and prolactin responses to TRH as predictors of the therapeutic effect of ECT in depression.

作者信息

Lykouras L, Markianos M, Augoustides A, Papakostas Y, Stefanis C

机构信息

Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece.

出版信息

Eur Neuropsychopharmacol. 1993 Jun;3(2):81-3. doi: 10.1016/0924-977x(93)90258-n.

DOI:10.1016/0924-977x(93)90258-n

PMID:8364352

Abstract

In a group of 42 unipolar depressed patients with melancholia the thyrotropin (TSH) and prolactin (PRL) responses to TRH were studied in relation to the clinical response to an ECT course. Patients were categorized as responders or nonresponders using as criterion a 50% reduction in the Hamilton Rating Scale for Depression score. Comparison between responders and nonresponders with respect to the TSH and PRL responses to TRH did not reveal any significant differences. Thus, TSH and PRL responses were not proved to have a predictive value for the therapeutic ECT response in melancholia.

摘要

在一组42例患有忧郁症的单相抑郁症患者中，研究了促甲状腺激素（TSH）和催乳素（PRL）对促甲状腺激素释放激素（TRH）的反应与电休克治疗（ECT）疗程临床反应之间的关系。以汉密尔顿抑郁量表评分降低50%为标准，将患者分为反应者和无反应者。反应者和无反应者在TSH和PRL对TRH反应方面的比较未发现任何显著差异。因此，TSH和PRL反应未被证明对忧郁症的ECT治疗反应具有预测价值。