Papakostas Y, Markianos M, Pehlivanidis A, Papadimitriou G N, Zervas I M, Daras M, Stefanis C
Department of Psychiatry Athens University Medical School, Greece.
Biol Psychiatry. 1996 Mar 15;39(6):444-7. doi: 10.1016/0006-3223(95)00198-0.
The effects of thyrotropin-releasing hormone (TRH) administration on electroconvulsive therapy (ECT)-induced prolactin (PRL) secretion and the duration of the seizure were studied in 14 depressed women. In a balanced order crossover design the patients were given 0.4 mg TRH or placebo intravenously 20 min before ECT during the first two sessions. In the third ECT session TRH was given just prior to ECT. ECT elicited the expected PRL response when given alone and when given 20 min after TRH when PRL plasma levels were high. During the coadministration design (third ECT session) PRL levels were raised not as a sum of the two stimuli but even significantly more. TRH failed to modify the duration of the seizure induced by ECT. Therefore, if TRH is involved in seizure modulation during ECT, our findings suggest a postictal rather than ictal role for TRH.
对14名抑郁症女性患者研究了促甲状腺激素释放激素（TRH）给药对电休克治疗（ECT）诱导的催乳素（PRL）分泌及癫痫发作持续时间的影响。采用平衡顺序交叉设计，在前两个疗程中，患者在ECT前20分钟静脉注射0.4毫克TRH或安慰剂。在第三个ECT疗程中，TRH在ECT即将进行前给药。单独给予ECT时以及在PRL血浆水平较高时TRH给药20分钟后给予ECT时，均引发了预期的PRL反应。在联合给药设计（第三个ECT疗程）期间，PRL水平升高并非两种刺激的叠加，而是甚至显著更高。TRH未能改变ECT诱导的癫痫发作持续时间。因此，如果TRH参与ECT期间的癫痫发作调节，我们的研究结果提示TRH起的是发作后而非发作期作用。
