一种使用去卵巢大鼠的急性局灶性骨质减少模型：鲑鱼降钙素保护作用的快速检测。
An acute and focal osteopenia model using ovariectomized rats: a rapid detection of the protective effect of salmon calcitonin.
作者信息
Nakamuta H, Sasaki M, Ichikawa M, Koida M
机构信息
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
出版信息
Biol Pharm Bull. 1993 Mar;16(3):325-7. doi: 10.1248/bpb.16.325.
A screening method for anti-osteoporotics using ovariectomized rats was designed using a compact method to monitor the bone density. It was found that ovariectomy (OVX) of Wistar female rats (11 weeks old) induced acute and focal osteopenia within 2 weeks, which responded well to intermittent salmon calcitonin (SCT: 5 and 20 U/kg, s.c., every other day) employed as the standard anti-osteoporotic and injected up to 4 weeks with or without a delay of 2 weeks after OVX.
采用一种简便方法监测骨密度，设计了一种使用去卵巢大鼠筛选抗骨质疏松药物的方法。结果发现，对11周龄的Wistar雌性大鼠进行卵巢切除术（OVX）后，2周内会诱发急性局灶性骨质减少，其对作为标准抗骨质疏松药物的鲑鱼降钙素（SCT：5和20 U/kg，皮下注射，隔日一次）反应良好，在去卵巢后无论是否延迟2周，均皮下注射鲑鱼降钙素长达4周。
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