Nanbo T
Daiichi Pure Chemicals Co., Ltd., Ibaraki, Japan.
Biol Pharm Bull. 1993 May;16(5):518-20. doi: 10.1248/bpb.16.518.
Rats were fed corn oil-free or corn oil-containing diets for 4 weeks to determine their effect on the competition between glucuronidation and sulfation in phenol and its para substituents. The activities of uridine diphosphate-glucuronyltransferase (UDPGT) on chemicals were enhanced with a 12% corn oil diet, whereas sulfotransferase activity showed no significant change. Following the intravenous injection of p-ethylphenol and p-tert-butylphenol, an increase of glucuronide and a decrease of sulfate were observed in the rats fed the corn oil diet. In contrast, no significant changes were observed in phenol and p-phenylphenol. These results are discussed in association with van der Waals volume (Vw) of substituent and phospholipid dependence of UDPGT.
大鼠分别喂食不含玉米油或含玉米油的饲料4周，以确定其对苯酚及其对位取代物的葡萄糖醛酸化和硫酸化竞争的影响。12%玉米油饮食可增强化学物质的尿苷二磷酸葡萄糖醛酸基转移酶（UDPGT）活性，而硫酸转移酶活性无显著变化。静脉注射对乙基苯酚和对叔丁基苯酚后，喂食玉米油饮食的大鼠体内葡萄糖醛酸苷增加，硫酸盐减少。相比之下，苯酚和对苯基苯酚未观察到显著变化。结合取代基的范德华体积（Vw）和UDPGT的磷脂依赖性对这些结果进行了讨论。
