Hazinski M F, Iberti T J, MacIntyre N R, Parker M M, Tribett D, Prion S, Chmel H
Division of Trauma, Vanderbilt University Medical Center, Nashville, TN 37212.
Am J Crit Care. 1993 May;2(3):224-35; quiz 236-7.
To review the epidemiology and pathophysiology of gram-negative sepsis and the new consensus terminology describing the clinical signs of sepsis.
Review of the medical literature and compiled data from animal and clinical trials.
Members of the Society of Critical Care Medicine, American College of Chest Physicians and American Association of Critical-Care Nurses with expertise on the subject of sepsis and its complications.
Preconference and general sessions were offered at the National Teaching Institutes of the American Association of Critical-Care Nurses, with the goal of clarifying the epidemiology, risk factors and pathophysiology of gram-negative sepsis. In addition, current terminology and new (1992) consensus terminology describing the clinical signs of sepsis were presented. Special emphasis was placed on the role of the healthcare provider in the prevention and recognition of sepsis and the role of the septic mediators in the septic cascade.
If the incidence of sepsis is to be reduced, the healthcare provider must be aware of the risk factors for sepsis and methods of reducing nosocomial infections. A thorough understanding of the role of mediators and consensus terminology used to describe sepsis, severe sepsis, septic shock and multiple organ dysfunction syndrome is necessary to recognize early or progressive signs of sepsis and to initiate state-of-the-art therapy.
回顾革兰阴性菌败血症的流行病学和病理生理学，以及描述败血症临床体征的新的共识术语。
医学文献综述以及动物和临床试验的汇总数据。
重症监护医学学会、美国胸科医师学会和美国重症护理护士协会中在败血症及其并发症领域具有专业知识的成员。
在美国重症护理护士协会的国家教学机构举办了会前会议和全体会议，目的是阐明革兰阴性菌败血症的流行病学、危险因素和病理生理学。此外，还介绍了描述败血症临床体征的当前术语和新的（1992年）共识术语。特别强调了医疗保健提供者在败血症预防和识别中的作用以及败血症介质在败血症级联反应中的作用。
若要降低败血症的发病率，医疗保健提供者必须了解败血症的危险因素以及减少医院感染的方法。全面理解介质的作用以及用于描述败血症、严重败血症、感染性休克和多器官功能障碍综合征的共识术语，对于识别败血症的早期或进展性体征并启动最新治疗至关重要。
