Ohsawa M, Aozasa K, Horiuchi K, Kanamaru A
Department of Pathology, Osaka University School of Medicine, Japan.
Cancer. 1993 Sep 15;72(6):1969-74. doi: 10.1002/1097-0142(19930915)72:6<1969::aid-cncr2820720630>3.0.co;2-a.
The significance of long-standing cystitis has been postulated as a causal factor in malignant lymphoma of bladder.
The authors reviewed 3 cases of primary malignant lymphoma of the urinary bladder and an additional 27 cases described in the literature (25 from Western countries and 2 from Japan). Clinical and pathologic findings in the total 30 cases are summarized.
The majority of patients presented with gross hematuria and were between 20 and 85 years of age (median age, 64 years). Marked female preponderance was found (male to female ratio, 1:6.5). Six patients (20%), all of whom were women, out of 30 had a history of chronic cystitis. Macroscopic findings showed a solitary mass (22 cases), multiple masses (6 cases), or a diffuse lesion without nodule formation (2 cases). The vast majority of bladder lymphoma were non-Hodgkin lymphoma (NHL) of B-cell type; among them, 14% were follicular lymphomas. Follow-up indicated that NHL of bladder had a favorable prognosis.
Malignant lymphoma of bladder is characterized by a preponderance in women, who are occasionally affected by chronic cystitis.
长期膀胱炎的意义已被假定为膀胱恶性淋巴瘤的一个致病因素。
作者回顾了3例原发性膀胱恶性淋巴瘤病例以及文献中描述的另外27例病例（25例来自西方国家，2例来自日本）。总结了这30例病例的临床和病理结果。
大多数患者表现为肉眼血尿，年龄在20至85岁之间（中位年龄64岁）。发现女性明显居多（男女比例为1:6.5）。30例患者中有6例（20%）有慢性膀胱炎病史，均为女性。宏观表现显示为单个肿块（22例）、多个肿块（6例）或无结节形成的弥漫性病变（2例）。绝大多数膀胱淋巴瘤为B细胞型非霍奇金淋巴瘤（NHL）；其中，14%为滤泡性淋巴瘤。随访表明膀胱NHL预后良好。
膀胱恶性淋巴瘤的特点是女性居多，她们偶尔会受到慢性膀胱炎的影响。
