5H,11H-[1]苯并吡喃并[4,3-g]苯并吡喃-9-羧酸的合成及构效关系
Synthesis and structure-activity relationships of 5H,11 H-[I]benzopyrano[4,3-g]benzopyran-9-carboxylic acids.
作者信息
Devlin J P, Freter K, Stewart P B
出版信息
J Med Chem. 1977 Feb;20(2):205-9. doi: 10.1021/jm00212a004.
PMID:836491
Abstract
The synthesis and properties of the title compounds 1 are described. Many of these compounds are potent inhibitors of the passive cutaneous anaphylaxis reaction of rats against egg albumin challenge. Structural variations include substitutions in the 2, 3, 4, 5, 7, and 12 position of the nucleus 1. A novel rearrangement from a compound of the related [3,4-f] series to this group is reported.
摘要
本文描述了标题化合物1的合成及性质。这些化合物中的许多都是大鼠针对卵清蛋白激发的被动皮肤过敏反应的有效抑制剂。结构变化包括在核1的2、3、4、5、7和12位上的取代。报道了一种从相关[3,4-f]系列化合物到该类化合物的新型重排。
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