Murata Y, Denda A, Maruyama H, Konishi Y
Department of Oncological Pathology, Nara Medical College, Japan.
Fundam Appl Toxicol. 1993 Jul;21(1):44-51. doi: 10.1006/faat.1993.1070.
The carcinogenic potential of 1-methylnaphthalene (1-MN), a compound which exists widely in the environment, was investigated in B6C3F1 mice. Groups of 50 male and 50 female mice were given diets containing 0, 0.075, or 0.15% 1-MN for 81 weeks. Both treatment groups developed pulmonary alveolar proteinosis at high incidence, with 46.0 and 34.7% of females and 46.0 and 38.0% of males, respectively, being affected. Total lipid and phospholipid levels in sera and monocytes in peripheral blood were also significantly increased in 1-MN-treated female and male mice in contrast with control values. The incidences of bronchiolar/alveolar adenomas in the lungs of male mice given both 0.075 or 0.15% 1-MN were 26.0 and 24.0%, respectively, in both cases significantly increased in contrast with the 4.1% observed for control males. However, neither dose dependence nor significant difference in the incidences of bronchiolar/alveolar carcinomas between 1-MN-treated and control male mice was observed. The incidences of other tumors also were similar in both 1-MN-treated and control groups. The results of the present experiment thus suggested a possible weak carcinogenic potential of 1-MN to the lung of male but not female B6C3F1 mice.
1-甲基萘（1-MN）是一种广泛存在于环境中的化合物，本研究在B6C3F1小鼠中对其致癌潜力进行了调查。将50只雄性和50只雌性小鼠分为几组，分别给予含0%、0.075%或0.15% 1-MN的饲料，持续81周。两个处理组的肺泡蛋白沉积症发病率均很高，雌性小鼠的发病率分别为46.0%和34.7%，雄性小鼠的发病率分别为46.0%和38.0%。与对照组相比，经1-MN处理的雌性和雄性小鼠血清和外周血单核细胞中的总脂质和磷脂水平也显著升高。给予0.075%或0.15% 1-MN的雄性小鼠肺中细支气管/肺泡腺瘤的发病率分别为26.0%和24.0%，与对照雄性小鼠观察到的4.1%相比，两种情况下均显著增加。然而，在经1-MN处理的雄性小鼠和对照雄性小鼠之间，未观察到细支气管/肺泡癌发病率的剂量依赖性或显著差异。1-MN处理组和对照组的其他肿瘤发病率也相似。因此，本实验结果表明，1-MN对雄性B6C3F1小鼠的肺可能具有较弱的致癌潜力，而对雌性小鼠则不然。
