Murata Y, Denda A, Maruyama H, Nakae D, Tsutsumi M, Tsujiuchi T, Konishi Y
Cancer Center, Nara Medical University, Shijo-cho 840, Kashihara, Nara, Japan.
Fundam Appl Toxicol. 1997 Mar;36(1):90-3. doi: 10.1006/faat.1996.2283.
The toxicity and carcinogenic potential of 2-methylnaphthalene (2-MN) were examined in B6C3F1 mice. Groups of 50 male and 50 female mice were given diets containing 0, 0.075, and 0.15% 2-MN for 81 weeks. Both 0.075 and 0.15% 2-MN caused pulmonary alveolar proteinosis at high incidence: 55.1 and 45.8% in females and 42.9 and 46.9% in males, respectively. The incidences of total lung tumors, including bronchiolar/alveolar adenomas and carcinomas, were 20.4 and 12.2% in male mice given 0.075 and 0.15% 2-MN, respectively, the former value being significantly increased compared with the 4. 1% in control males. However, in the respective incidences of the adenomas and carcinomas, neither intergroup differences nor dose dependencies were observed. The incidences of other tumors did not differ between mice treated with 2-MN and the controls. The results indicated that 2-MN induces pulmonary alveolar proteinosis but does not possess unequivocal carcinogenic potential in B6C3F1 mice.
在B6C3F1小鼠中检测了2-甲基萘（2-MN）的毒性和致癌潜力。将50只雄性和50只雌性小鼠分为几组，给予含0%、0.075%和0.15% 2-MN的饮食，持续81周。0.075%和0.15%的2-MN均导致肺泡蛋白沉积症的高发病率：雌性分别为55.1%和45.8%，雄性分别为42.9%和46.9%。在给予0.075%和0.15% 2-MN的雄性小鼠中，包括细支气管/肺泡腺瘤和癌在内的总肺肿瘤发生率分别为20.4%和12.2%，与对照雄性小鼠的4.1%相比，前者显著增加。然而，在腺瘤和癌的各自发生率中，未观察到组间差异和剂量依赖性。用2-MN处理的小鼠与对照小鼠之间其他肿瘤的发生率没有差异。结果表明，2-MN可诱导肺泡蛋白沉积症，但在B6C3F1小鼠中不具有明确的致癌潜力。
