Colman G, Tanna A, Efstratiou A, Gaworzewska E T
Division of Hospital Infection, Central Public Health Laboratory, London.
J Med Microbiol. 1993 Sep;39(3):165-78. doi: 10.1099/00222615-39-3-165.
A total of 16,909 cultures of Streptococcus pyogenes (Lancefield group A) isolated in Britain during 1980-90 were examined for T- and M-protein antigens. One or other M antigen was detected in 92.6% of the strains. The numbers of isolates of some serotypes, such as M3 and M12, did not show great variation from year-to-year, whereas there were nationwide epidemics, extending over several years, caused by strains of serotypes M1 and M49. Isolates of serotypes M1 and M3 were associated particularly with invasive disease and fatal infections. Representatives of serotypes M80, M81 and the provisional types PT180, PT1658 and PT5757 were isolated most often from cases of pyoderma. Erythromycin resistance was detected in 30 serotypes but one half of all of the resistant isolates belonged to serotype M4.
对1980年至1990年间在英国分离出的总共16909株化脓性链球菌（A群兰氏菌）培养物进行了T蛋白和M蛋白抗原检测。在92.6%的菌株中检测到了一种或另一种M抗原。某些血清型（如M3和M12）的分离株数量年际变化不大，而血清型M1和M49的菌株引发了持续数年的全国性流行。血清型M1和M3的分离株尤其与侵袭性疾病和致命感染有关。血清型M80、M81以及暂定类型PT180、PT1658和PT5757的代表菌株最常从脓皮病病例中分离出来。在30种血清型中检测到了红霉素耐药性，但所有耐药分离株的一半属于血清型M4。
