[人类白细胞抗原-DRW抗原与多发性硬化症]
[HLA-DRW antigens and multiple sclerosis].
作者信息
De Moerloose P H, Jeannet M, Martins-da-Silva B, Werner-Favre C, Rohr J, Gauthier G
出版信息
Schweiz Arch Neurol Neurochir Psychiatr. 1978;123(1):51-61.
Previous studies of multiple sclerosis patients showed the existence of a positive association between multiple sclerosis and HLA-A3 and B7, as well as a negative association with B12, These observations have been confirmed. In addition, a more marked association has been observed with two recently identified B-cell antigens, DRW2 and DRW3, closely related to HLA-D locus. The presence of cold lymphocytotoxic antibodies was found to bear no relationship with those two specificities. These results suggest that two genes of the HLA-DR region may play a role in the pathogenesis of multiple sclerosis.
先前对多发性硬化症患者的研究表明，多发性硬化症与HLA - A3和B7之间存在正相关，与B12存在负相关，这些观察结果已得到证实。此外，还观察到与两种最近发现的B细胞抗原DRW2和DRW3有更显著的关联，它们与HLA - D位点密切相关。发现冷淋巴细胞毒性抗体的存在与这两种特异性无关。这些结果表明，HLA - DR区域的两个基因可能在多发性硬化症的发病机制中起作用。
Zotero 插件