Bertrams H J, Kuwert E K
J Immunol. 1976 Nov;117(5 Pt.2):1906-12.
Tissue typing was performed on 1000 unrelated multiple sclerosis (MS) patients and 1000 unrelated healthy controls. In addition, segregation analysis of HLA antigens and haplotypes in 36 MS families was done. The following results were observed: HLA-A3 and HLA-B7 were found significantly more often in MS individuals; haplotype HLA-A3-B7 was observed significantly more often in MS patients than in healthy indiciduals of the same population; the association between HLA-A3 and HLA-B7 was signigicantly stronger in MS patients than in controls; the haplotype HLA-A3-B7 shows a common segregation with the disease multiple sclerosis (p = 0.02); and the hypothetical "MS-disease-susceptibility-gene" may be located between the second locus and the HLA region and the MLC (mixed lymphocyte culture)-histocompatibility-determinant-region on chromosome No. 6.
对1000名无亲缘关系的多发性硬化症（MS）患者和1000名无亲缘关系的健康对照者进行了组织分型。此外，还对36个MS家系中的HLA抗原和单倍型进行了分离分析。观察到以下结果：HLA - A3和HLA - B7在MS个体中出现的频率明显更高；单倍型HLA - A3 - B7在MS患者中出现的频率明显高于同一人群中的健康个体；HLA - A3和HLA - B7之间的关联在MS患者中比在对照中明显更强；单倍型HLA - A3 - B7与多发性硬化症疾病表现出共同分离（p = 0.02）；并且假设的“MS疾病易感性基因”可能位于6号染色体上的第二个基因座与HLA区域以及混合淋巴细胞培养 - 组织相容性决定区域之间。
