出血和褪黑素对松果体切除雄性大鼠神经垂体加压素和催产素含量的影响。
The effect of haemorrhage and melatonin on neurohypophysial vasopressin and oxytocin content in pinealectomized male rats.
作者信息
Juszczak M
机构信息
Department of Pathophysiology, University School of Medicine, Lódź.
出版信息
Patol Pol. 1993;44(2):61-4.
The effect of haemorrhage and melatonin on the vasopressin and oxytocin storage in the neurohypophysis of pinealectomized male rats was determined. Sham operated or pinealectomized rats as well as rats pinealectomized and injected with melatonin (100 micrograms/100 g b. w., once daily over 8 days) or with melatonin vehicle (2.2% ethanol in 0.9% NaCl) were subsequently subjected to haemorrhage. Pinealectomy was followed by known decrease of both vasopressin and oxytocin content in the neurohypophysis as compared to sham operated rats. Similarly, haemorrhage decreased the neurohypophysial vasopressin and oxytocin storage in both sham operated and pinealectomized animals. Melatonin, injected to pinealectomized animals, did not modify the diminution of neurohypophysial vasopressin and oxytocin content caused by bleeding. The results demonstrate that in pinealectomized rats melatonin does not affect the rate of the response of vasopressinergic and oxytocinergic neurones to bleeding.
研究了出血和褪黑素对去松果体雄性大鼠神经垂体中血管加压素和催产素储存的影响。对假手术或去松果体大鼠，以及去松果体并注射褪黑素（100微克/100克体重，连续8天每天一次）或褪黑素溶媒（0.9%氯化钠中的2.2%乙醇）的大鼠随后进行出血处理。与假手术大鼠相比，去松果体后神经垂体中血管加压素和催产素含量均出现已知的下降。同样，出血使假手术和去松果体动物的神经垂体血管加压素和催产素储存减少。给去松果体动物注射褪黑素，并未改变出血所致神经垂体血管加压素和催产素含量的减少。结果表明，在去松果体大鼠中，褪黑素不影响血管加压素能和催产素能神经元对出血的反应速率。
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