大鼠体内（3(-14)C）香豆素的组织水平：分布与排泄
Tissue levels of (3(-14)C) coumarin in the rat: distribution and excretion.
作者信息
Piller N B
出版信息
Br J Exp Pathol. 1977 Feb;58(1):28-34.
The benzo-pyrones (including coumarin) are a very effective therapy for mild thermal oedema and cases of acute and chronic lymphoedema. In this preliminary report the distribution of a single injected dose of coumarin was followed in normal tissues of rats for 100 hours. Comparisons are to be made later with drug levels in thermally injured and lymphoedematous tissues. The resluts show 7-4% of the injected dose to remain in the tissues after 100 h. During this time 30-9% was excreted in the faeces and approximately 47% excreted in the urine. At any given time most of the dose was present in the gut, muscular tissues, skin and liver. For the gut tissues this was 33%, for the muscular tissues 28%, for the skin 18% and for the liver 16%. The highest concentrations per gram of tissue were however in the kidney and liver, representing the two organs of metabolism and excretion of the coumarin.
苯并吡喃（包括香豆素）是治疗轻度热水肿以及急慢性淋巴水肿的一种非常有效的疗法。在这份初步报告中，对大鼠正常组织中单次注射香豆素剂量后的分布情况进行了100小时的跟踪。后续将对热损伤组织和淋巴水肿组织中的药物水平进行比较。结果显示，100小时后，7.4%的注射剂量残留在组织中。在此期间，30.9%经粪便排出，约47%经尿液排出。在任何给定时间，大部分剂量存在于肠道、肌肉组织、皮肤和肝脏中。肠道组织中占33%，肌肉组织中占28%，皮肤中占18%，肝脏中占16%。然而，每克组织中浓度最高的是肾脏和肝脏，它们是香豆素代谢和排泄的两个器官。
Zotero 插件