单次注射后大鼠组织中（3-14C）香豆素的分布。

(3-14C) coumarin distribution in rat tissues after the injection of a single dose.

作者信息

Piller N B

出版信息

Res Exp Med (Berl). 1977 Aug 16;171(1):93-100. doi: 10.1007/BF01851592.

Abstract

Experimentally it has been shown that coumarin is a very effective therapy in the treatment of high protein oedemas. This study reports on the distribution of a single dose of 3-14C-coumarin in rats. Blood levels of coumarin were always much lower than those of the tissues at similar times. The half life of 3-14C-coumarin and its labelled metabolites was found to be about 43 hours. This ties in fairly well with the optimum frequencies of the administration of the drug which was found to be 24 hours. At this time, skin and muscle levels (the tissues most effected in lymphoedema and in thermal oedema) were maximal.

摘要

实验表明，香豆素在治疗高蛋白水肿方面是一种非常有效的疗法。本研究报告了单剂量的3-¹⁴C-香豆素在大鼠体内的分布情况。在相似时间，香豆素的血药浓度总是远低于组织中的浓度。发现3-¹⁴C-香豆素及其标记代谢物的半衰期约为43小时。这与该药物的最佳给药频率（24小时）相当吻合。此时，皮肤和肌肉中的浓度（在淋巴水肿和热水肿中受影响最大的组织）达到最高。