Breda S, Richter H P, Schachenmayr W
Institut für Neuropathologie, Justus-Liebig-Universität Giessen.
Zentralbl Neurochir. 1993;54(2):72-6.
Histological examination of surgical specimens from 98 patients with carpal tunnel syndrome revealed amyloid deposits in 12% of the cases. Amyloid was located in the flexor retinaculum and to the same extent in the tenosynovium. Serial sections of the material containing amyloid deposits demonstrated that examination of only one level would detect solely 90% of the amyloid-positive cases. In one single case amyloid deposits were considered extensive enough to cause compression of the median nerve and thus could have played a role in the pathogenesis of the carpal tunnel syndrome. In 8 of the 12 cases the patients' histories proved no correlation to preexisting diseases. In our opinion, an individual disposition may promote amyloid deposits as a response to local and chronic irritation. It is noteworthy that the mean age in the amyloid-positive group (70 years) is significantly higher than in the amyloid-negative cases (55 years).
对98例腕管综合征患者手术标本进行组织学检查发现，12%的病例存在淀粉样沉积。淀粉样物质位于屈肌支持带，在腱鞘中的沉积程度相同。对含有淀粉样沉积的材料进行连续切片显示，仅检查一个层面只能检测出90%的淀粉样阳性病例。在1例中，淀粉样沉积被认为广泛到足以压迫正中神经，因此可能在腕管综合征的发病机制中起作用。在12例中的8例中，患者病史证明与既往疾病无相关性。我们认为，个体易感性可能促使淀粉样沉积作为对局部和慢性刺激的一种反应。值得注意的是，淀粉样阳性组的平均年龄（70岁）显著高于淀粉样阴性病例组（55岁）。
