Wegner C D, Gundel R H, Letts L G
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
Agents Actions Suppl. 1993;43:151-62. doi: 10.1007/978-3-0348-7324-6_13.
Cell surface adhesive glycoproteins are principal regulators of nearly all aspects of immune/inflammatory responses. Using monoclonal antibodies to individual adhesion molecules, the expression and contribution of specific molecules in the pathogenesis of allergen-induced airway hyperresponsiveness in monkeys has been deciphered. Results confirm the importance of cell adhesion and demonstrate that antagonism of a single adhesion molecule may provide a novel therapeutic approach.
细胞表面黏附糖蛋白几乎是免疫/炎症反应所有方面的主要调节因子。利用针对单个黏附分子的单克隆抗体，已阐明了特定分子在猴子变应原诱导的气道高反应性发病机制中的表达及作用。结果证实了细胞黏附的重要性，并表明拮抗单一黏附分子可能提供一种新的治疗方法。
