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Freeze-fracture electron microscopy of human erythrocytes lacking the major membrane sialoglycoprotein.

作者信息

Bächi T, Whiting K, Tanner M J, Metaxas M N, Anstee D J

出版信息

Biochim Biophys Acta. 1977 Feb 4;464(3):635-9. doi: 10.1016/0005-2736(77)90039-6.

Abstract

Human erythrocytes of blood group En (a-), a rare homozygous condition involving a complete lack of the major sialoglycoprotein of the cell membrane (glycophorin A), were compared with erythrocytes from normal (En (a+)) individuals by freeze-fracture electron microscopy. No decrease in number, or variation in morphology, of the intramembranal particles of En (a-) cells was detectable. The results show that the erythrocyte sialoglycoprotein is not essential for the maintenance of the integrity of the intramembranal particles of the human erythrocyte membrane.

摘要

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