Katz Y, Goldberg N, Kivity S
Allergy and Immunology Unit, Assaf Harofeh Medical Center, Zerifin, Israel.
Allergy. 1993 Jul;48(5):366-9. doi: 10.1111/j.1398-9995.1993.tb02407.x.
We documented localized periorbital edema in two patients with aspirin sensitivity without underlying chronic urticaria. The reaction developed 30 min after ingestion of 62.5 and 125 mg of aspirin, respectively. No systemic symptoms were observed. Other NSAIDs did not induce symptoms. These patients were able to tolerate doses of aspirin after pretreatment with terfenadine. These observations suggest that histamine plays a central role in aspirin-induced skin reaction. Despite the fact that terfenadine blocks the drug-induced reaction, this protocol should be used with caution and only where there is no feasible alternative to aspirin.
我们记录了两名无潜在慢性荨麻疹的阿司匹林敏感患者出现局限性眶周水肿。分别在摄入62.5毫克和125毫克阿司匹林后30分钟出现该反应。未观察到全身症状。其他非甾体抗炎药未诱发症状。这些患者在接受特非那定预处理后能够耐受阿司匹林剂量。这些观察结果表明组胺在阿司匹林诱发的皮肤反应中起核心作用。尽管特非那定可阻断药物诱发的反应，但该方案应谨慎使用，且仅适用于没有可行的阿司匹林替代药物的情况。
