Rafiq Raheela
Walsall Manor Hospital, Moat Road, Walsall, West Midlands WS2 9PS, UK.
Dent Update. 2007 Jun;34(5):302-4. doi: 10.12968/denu.2007.34.5.302.
Periorbital angio-oedema may present as an isolated manifestation of aspirin intolerance and can be very alarming to the patient. This case describes a 38-year-old gentleman with such localized clinical features. Once considered an unusual phenomenon, review of the literature has revealed an increased frequency, possibly as a result of previous poor documentation. Clinical manifestations of nonsteroidal anti-inflammatory drugs (NSAIDs) intolerance, in particular periorbital angio-oedema and its associated symptoms, with proposed aetiology and pathogenesis, are discussed.
With the wide use of this drug and other NSAIDs for the relief of painful and inflammatory dental and facial conditions, such localized manifestation of aspirin intolerance may present to the general dental practitioner and other dental specialties. Patients' medical history may reveal sensitivity to these groups of drugs, and in such cases, should be avoided and suitable alternatives provided.
眶周血管性水肿可能是阿司匹林不耐受的孤立表现，这会让患者非常惊恐。本病例描述了一位具有此类局部临床特征的38岁男性。眶周血管性水肿曾被认为是一种不常见的现象，但文献回顾显示其发生率有所增加，可能是由于之前记录不佳所致。本文讨论了非甾体抗炎药（NSAIDs）不耐受的临床表现，特别是眶周血管性水肿及其相关症状，并提出了病因和发病机制。
随着这种药物和其他NSAIDs广泛用于缓解牙齿和面部的疼痛及炎症，阿司匹林不耐受的这种局部表现可能会出现在普通牙科医生和其他牙科专科面前。患者的病史可能显示对这些药物敏感，在这种情况下，应避免使用并提供合适的替代药物。
