对雷尼替丁的过敏反应。

Anaphylactic reaction to ranitidine.

作者信息

Lázaro M, Compaired J A, De La Hoz B, Igea J M, Marcos C, Dávila I, Losada E

机构信息

Servicio de Alergia, Hospital Ramón y Cajal, Madrid, Spain.

出版信息

Allergy. 1993 Jul;48(5):385-7. doi: 10.1111/j.1398-9995.1993.tb02412.x.

DOI:10.1111/j.1398-9995.1993.tb02412.x

PMID:8368468

Abstract

Ranitidine is a well-tolerated H2-receptor antagonist with a furan ring as nucleus. Anaphylactic reactions are seldom reported despite the wide use of the drug. We report a patient who presented an anaphylactic reaction with ranitidine (Zantac). The positive skin prick test and oral challenge suggest type I hypersensitivity. Specific IgE determination by RAST technique and histamine release test with ranitidine were negative. The patient did not react to other H2-receptor antagonists or to another furan-derivative (nitrofurantoin).

摘要

雷尼替丁是一种耐受性良好的以呋喃环为核心的H2受体拮抗剂。尽管该药物广泛使用，但很少有过敏反应的报道。我们报告了一名使用雷尼替丁（善胃得）出现过敏反应的患者。皮肤点刺试验阳性和口服激发试验提示I型超敏反应。通过放射性变应原吸附试验技术测定特异性IgE以及雷尼替丁组胺释放试验均为阴性。该患者对其他H2受体拮抗剂或另一种呋喃衍生物（呋喃妥因）无反应。