儿童对23价肺炎球菌疫苗的过敏反应：一项基于皮肤试验即时反应和特异性IgE测定的病例对照研究。

Anaphylaxis to the 23-valent pneumococcal vaccine in child: a case-control study based on immediate responses in skin tests and specific IgE determination.

作者信息

Ponvert C, Ardelean-Jaby D, Colin-Gorski A M, Soufflet B, Hamberger C, de Blic J, Scheinmann P

机构信息

Department of Medicine, Paris VI University, Paediatric Pulmonology & Allergy Service, Sick Children Hospital, 149 rue de Sèvres, 75015, Paris, France.

出版信息

Vaccine. 2001 Sep 14;19(32):4588-91. doi: 10.1016/s0264-410x(01)00257-2.

DOI:10.1016/s0264-410x(01)00257-2

PMID:11535304

Abstract

Injections of the 23-valent pneumococcal vaccine are usually well tolerated. Skin tests (prick and intradermal) and a self-made RAST with pneumococcal vaccine and phenol were performed in a child reporting a severe anaphylactic reaction induced by a 23-valent pneumococcal vaccine, and in ten control children, including one child with a well-tolerated vaccination, and nine non-vaccinated children. Skin tests and RAST with the vaccine were positive in the child reporting anaphylaxis, and negative in nine of the control children. Intradermal test with the vaccine was slightly positive in a non-vaccinated child with negative RAST. Skin tests and RAST with phenol were negative in all the children. These results suggest that immediate responses in skin tests and specific IgE determination have a good diagnostic value in children reporting severe reactions suggestive of IgE-dependent hypersensitivity to pneumococcal vaccine.

摘要

23价肺炎球菌疫苗注射通常耐受性良好。对一名报告由23价肺炎球菌疫苗引发严重过敏反应的儿童以及十名对照儿童进行了皮肤试验（点刺和皮内试验），以及用肺炎球菌疫苗和苯酚自制的放射性变应原吸附试验（RAST），对照儿童包括一名疫苗接种耐受性良好的儿童和九名未接种疫苗的儿童。报告过敏反应的儿童中，疫苗皮肤试验和RAST呈阳性，九名对照儿童呈阴性。一名RAST阴性的未接种疫苗儿童的疫苗皮内试验呈弱阳性。所有儿童的苯酚皮肤试验和RAST均为阴性。这些结果表明，对于报告提示对肺炎球菌疫苗存在IgE依赖性超敏反应的严重反应的儿童，皮肤试验和特异性IgE测定中的即时反应具有良好的诊断价值。