Nguyen T, Guinn O A, Wortham K, Rothkopf D M
Department of Surgery, University of Massachusetts Medical Center, Worcester 01655.
Ann Plast Surg. 1993 Jun;30(6):520-4. doi: 10.1097/00000637-199306000-00009.
The efficacy of ibuprofen in reducing microvascular thrombosis in a well-established experimental model was studied. Bilateral 2-mm arterial inversion grafts were constructed in the femoral arteries of New Zealand White rabbits. The experimental group (n = 40 grafts) received subcutaneous injections of ibuprofen 15 mg/kg t.i.d. beginning 1 day preoperatively and continued for 7 days postoperatively. The control group (n = 42 grafts) received injections of an equivalent volume of saline three times per day. Patency was evaluated at 7 days by the distal milking test. Seventy-three percent of the ibuprofen grafts were patent at 7 days, whereas 57% of the control grafts remained open. This difference in microvascular patency was not statistically significant. Representative scanning electron micrographs revealed a moderate reduction in aggregated platelets and overall clot density in the patent ibuprofen arterial inversion grafts compared with the patent control specimens. Although the use of ibuprofen as a sole antithrombotic agent cannot be recommended as the result of this study, it may be efficacious when used in conjunction with other agents such as dextran 40.
在一个成熟的实验模型中，研究了布洛芬在减少微血管血栓形成方面的疗效。在新西兰白兔的股动脉中构建双侧2毫米动脉倒置移植物。实验组（n = 40个移植物）从术前1天开始接受皮下注射布洛芬，剂量为15毫克/千克，每日3次，并持续至术后7天。对照组（n = 42个移植物）每天接受3次等量生理盐水注射。在第7天通过远端挤奶试验评估通畅情况。73%的布洛芬处理的移植物在第7天保持通畅，而对照组移植物的通畅率为57%。微血管通畅情况的这种差异无统计学意义。代表性扫描电子显微镜照片显示，与通畅的对照标本相比，通畅的布洛芬处理的动脉倒置移植物中聚集的血小板和总体血栓密度有适度降低。尽管根据本研究结果不推荐将布洛芬作为唯一的抗血栓药物使用，但与右旋糖酐40等其他药物联合使用时可能有效。
