Peters J L, Shaw D D
Utah Biomedical Testing Laboratory, Salt Lake City.
Acta Radiol. 1993 Sep;34(5):510-6.
A nonionic (gadodiamide injection) and an ionic (gadopentetate dimeglumine) contrast medium were compared for their effect on hemodynamics in the anesthetized, open-chest dog. Both agents were administered i.v. over 15 s at dosages of 1.0 and 1.5 mmol/kg, in randomized order. Both contrast agents resulted in transient but statistically significant decreases in aortic pressure, left ventricular pressure, indices of left ventricular contractility and relaxation, and systemic and pulmonary vascular resistance, and increases in aortic blood flow. At each dosage investigated, the changes associated with the administration of gadodiamide injection were of significantly smaller magnitude than those seen after gadopentetate dimeglumine and returned to preadministration levels sooner. The results from this study confirm that gadodiamide injection produces less severe alterations in hemodynamics than gadopentetate dimeglumine.
对一种非离子型（钆双胺注射液）和一种离子型（钆喷酸葡胺）造影剂在麻醉开胸犬体内对血流动力学的影响进行了比较。两种药物均以1.0和1.5 mmol/kg的剂量经静脉在15秒内给药，给药顺序随机。两种造影剂均导致主动脉压、左心室压、左心室收缩和舒张指标以及体循环和肺血管阻力出现短暂但具有统计学意义的下降，主动脉血流增加。在每个研究剂量下，与钆双胺注射液给药相关的变化幅度明显小于钆喷酸葡胺给药后观察到的变化幅度，且恢复到给药前水平的时间更快。本研究结果证实，钆双胺注射液对血流动力学的改变比钆喷酸葡胺轻。
