所有镍氢化酶的大亚基和小亚基与线粒体烟酰胺腺嘌呤二核苷酸（NADH）：泛醌氧化还原酶的两个核编码亚基的紧密关系。
Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.
作者信息
Albracht S P
机构信息
E.C. Slater Institute, BioCentrum, University of Amsterdam, The Netherlands.
出版信息
Biochim Biophys Acta. 1993 Sep 13;1144(2):221-4. doi: 10.1016/0005-2728(93)90176-g.
The sequence pattern CxxCxnGxCxxxGxmGCPP, thus far found in the small subunits from 21 different nickel hydrogenases, appears also to be present in the PSST polypeptide from NADH:ubiquinone oxidoreductase (Complex I) of beef-heart mitochondria. There is only one difference: the first cysteine residue is a leucine in the PSST subunit. The large nickel-binding subunit of nickel hydrogenases shows a surprising homology with the 49 kDa subunit of mitochondrial Complex I.
迄今为止，在21种不同的镍氢化酶的小亚基中发现的序列模式CxxCxnGxCxxxGxmGCPP，似乎也存在于牛心线粒体中烟酰胺腺嘌呤二核苷酸（NADH）：泛醌氧化还原酶（复合体I）的PSST多肽中。只有一个不同之处：在PSST亚基中，第一个半胱氨酸残基是亮氨酸。镍氢化酶的大的镍结合亚基与线粒体复合体I的49 kDa亚基显示出惊人的同源性。
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