Salmon S E, Wampler S B
Blood. 1977 Mar;49(3):379-89.
Studies of M-component synthesis and metabolism, as well as clinical staging of multiple myeloma, have provided the basis for calculation of the total body tumor cell number and quantitation of response to treatment. Many of the calculations involved have been complex and have previously required the availability of a computer. The advent of programmable pocket calculators has permitted simplification of these programs for general clinical and investigative applications in studies of myeloma and related monoclonal gammopathies. In this paper we have included the background information and a clinical example of the use of the programmable calculator, as well as the logic steps and the calculator programs themselves, for several of the most useful programs for clinical staging and quantitation of response to therapy in IgG myeloma.
对M蛋白合成与代谢的研究以及多发性骨髓瘤的临床分期，为计算全身肿瘤细胞数量和评估治疗反应的定量分析提供了依据。许多相关计算都很复杂，以前需要使用计算机。可编程袖珍计算器的出现使得这些程序得以简化，以便在骨髓瘤及相关单克隆丙种球蛋白病的研究中用于一般临床和研究应用。在本文中，我们纳入了背景信息、可编程计算器使用的临床实例，以及针对IgG骨髓瘤临床分期和治疗反应定量分析中几个最有用程序的逻辑步骤和计算器程序本身。
