Newton T F, Leuchter A F, Walter D O, Van Gorp W C, Stern C E, Mandelkern M, Weiner H
Department of Veterans Affairs Medical Center, West Los Angeles, CA 90073.
J Neuropsychiatry Clin Neurosci. 1993 Summer;5(3):316-21. doi: 10.1176/jnp.5.3.316.
The authors studied the relationship between cerebral metabolism and brain electrical activity in patients with acquired immunodeficiency syndrome (AIDS), using positron-emission tomography and quantitative electroencephalography. Electroencephalographic coherence in the 6-to 10-Hz band correlated positively with thalamic metabolic activity. Coherence adjusted for background activity correlated strongly and positively with basal ganglia metabolic activity. Posterior interhemispheric coherence showed the highest correlations with measures of metabolic activity. These results suggest that changes in coherence may reflect AIDS-related subcortical disease. The high correlations between the two different measures of cerebral activity support the validity of electroencephalographic coherence measures in studies of AIDS-related neuropsychiatric dysfunction.
作者使用正电子发射断层扫描和定量脑电图研究了获得性免疫缺陷综合征（AIDS）患者脑代谢与脑电活动之间的关系。6至10赫兹频段的脑电图相干性与丘脑代谢活动呈正相关。经背景活动调整后的相干性与基底神经节代谢活动呈强正相关。半球间后部相干性与代谢活动测量值的相关性最高。这些结果表明，相干性的变化可能反映了与AIDS相关的皮质下疾病。两种不同脑活动测量方法之间的高相关性支持了脑电图相干性测量在AIDS相关神经精神功能障碍研究中的有效性。
