Hori T, Fukuda M, Suzuki H, Yano S, Ono T
Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Clin Immunol Immunopathol. 1993 Sep;68(3):243-5. doi: 10.1006/clin.1993.1125.
The effects of stress due to specific alteration of rhythm of temperature (SART) on lymphocyte subpopulations of the thymus and spleen were examined in C3H/He mice. Thymic and splenic involution were evident in SART-stressed mice, and lymphocyte subpopulations were significantly changed. In the thymus, CD4+ CD8+ and CD3- or CD3low lymphocytes were decreased by SART stress more than other lymphocytes, and CD4- and CD8-single-positive lymphocytes and B lymphocytes in the spleen were decreased equally. Immunoregulation via the adrenal glands and sympathetic nervous system was studied in chemically sympathectomized and adrenalectomized SART-stressed mice. Neither chemical sympathectomy nor adrenalectomy alone influenced the thymus or spleen in nonstressed mice, but chemical sympathectomy enhanced SART stress-induced thymic changes and further decreased the number of B lymphocytes in the spleen of SART-stressed mice; adrenalectomy blocked SART stress-induced thymic changes and increased the number of B lymphocytes in the spleen. These findings indicate that the genesis of thymic changes induced by SART stress is in the adrenal glands, and malfunction of sympathetic nerves and insufficient excretion of adrenal hormones could alter the balance of lymphocytes in the spleen during stress. It was also clear that thymic changes induced by SART stress could be immediately reversed to pretest conditions by alleviating the stress.
在C3H/He小鼠中，研究了温度节律特定改变应激（SART）对胸腺和脾脏淋巴细胞亚群的影响。SART应激小鼠出现胸腺和脾脏萎缩，淋巴细胞亚群显著改变。在胸腺中，SART应激使CD4+CD8+以及CD3-或CD3低表达淋巴细胞比其他淋巴细胞减少得更多，而脾脏中的CD4-和CD8-单阳性淋巴细胞以及B淋巴细胞减少程度相同。在化学去交感神经和肾上腺切除的SART应激小鼠中，研究了通过肾上腺和交感神经系统的免疫调节。单独化学去交感神经或肾上腺切除对非应激小鼠的胸腺或脾脏均无影响，但化学去交感神经增强了SART应激诱导的胸腺变化，并进一步减少了SART应激小鼠脾脏中B淋巴细胞的数量；肾上腺切除则阻断了SART应激诱导的胸腺变化，并增加了脾脏中B淋巴细胞的数量。这些发现表明，SART应激诱导的胸腺变化起源于肾上腺，应激期间交感神经功能障碍和肾上腺激素分泌不足可能会改变脾脏中淋巴细胞的平衡。还清楚的是，通过减轻应激，SART应激诱导的胸腺变化可立即恢复到测试前状态。
