SART（反复冷刺激）应激动物的痛觉过敏与自主神经系统的关系。

The relationship of hyperalgesia in SART (repeated cold)-stressed animals to the autonomic nervous system.

Hata T, Kita T, Itoh E, Kawabata A

Department of Pharmacology, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.

J Auton Pharmacol. 1988 Mar;8(1):45-52. doi: 10.1111/j.1474-8673.1988.tb00168.x.

Abstract

The mechanism of hyperalgesia observed in SART (repeated cold)-stressed animals (mice and rats) was studied in relation to the autonomic nervous system. 2. SART stress reduced the nociceptive threshold previously increased in vagotomized mice, but failed to change the threshold previously decreased in sympathectomized mice. 3. The nociceptive threshold previously decreased in SART-stressed mice was elevated by vagotomy, but decreased still more by sympathectomy. 4. Lesion of ventromedial (VMH), anterior (AH) or posterior hypothalamus (PH) prevented decrease in the nociceptive threshold of rats by SART stress, but lesion of the lateral hypothalamus (LH) had no such effect. 5. The nociceptive threshold previously decreased in stressed rats did not change by VMH, AH or PH lesion, but increased by LH lesion. 6. The above findings indicate that hyperalgesia in SART-stressed animals apparently bears little relation to the parasympathetic nervous system, but is associated relatively more with reduced tone in the sympathetic nervous system.

摘要

研究了在经受SART（反复寒冷）应激的动物（小鼠和大鼠）中观察到的痛觉过敏机制与自主神经系统的关系。2. SART应激降低了迷走神经切断术小鼠先前升高的伤害性感受阈值，但未能改变交感神经切除术小鼠先前降低的阈值。3. 迷走神经切断术使SART应激小鼠先前降低的伤害性感受阈值升高，但交感神经切除术后进一步降低。4. 腹内侧（VMH）、前部（AH）或下丘脑后部（PH）损伤可防止SART应激导致大鼠伤害性感受阈值降低，但下丘脑外侧（LH）损伤则无此作用。5. 应激大鼠先前降低的伤害性感受阈值在VMH、AH或PH损伤后未改变，但在LH损伤后升高。6. 上述发现表明，SART应激动物的痛觉过敏显然与副交感神经系统关系不大，但与交感神经系统张力降低的相关性相对更大。