与毛细血管通透性相关的组胺受体的性质。
Nature of histamine receptors concerned in capillary permeability.
作者信息
Bhargava K P, Nath R, Palit G
出版信息
Br J Pharmacol. 1977 Feb;59(2):349-51. doi: 10.1111/j.1476-5381.1977.tb07499.x.
Abstract
1 Histamine and 2-methyl-histamine (H1-receptor agonist) caused dose-dependent increases in capillary permeability in albino mice, but 4-methyl-histamine (H2-receptor agonist) caused no significant increase. 2 Mepyramine (H1-receptor antagonist) blocked the histamine-induced increase in capillary permeability whereas burimamide (H2-receptor antagonist) produced no significant blockade of the histamine-response. 3 Combined mepyramine and burimamide pretreatment did not give any significantly greater protection than mepyramine alone. 4 The results indicate involvement of the H1-receptors in histamine-induced increase in capillary permeability.
摘要
1 组胺和2-甲基组胺（H1受体激动剂）可使白化小鼠的毛细血管通透性呈剂量依赖性增加，但4-甲基组胺（H2受体激动剂）未引起显著增加。2 美吡拉敏（H1受体拮抗剂）可阻断组胺诱导的毛细血管通透性增加，而布立马胺（H2受体拮抗剂）对组胺反应无显著阻断作用。3 联合使用美吡拉敏和布立马胺预处理并不比单独使用美吡拉敏提供更大的保护作用。4 结果表明H1受体参与了组胺诱导的毛细血管通透性增加。
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