Woodward D F, Spada C S, Hawley S B, Nieves A L
Agents Actions. 1985 Dec;17(2):121-5. doi: 10.1007/BF01966579.
Several substances alter eosinophil motility, but the relative importance of these putative mediators in immediate hypersensitivity remains unclear. The present study has re-investigated the role of histamine in type I allergic eosinophil infiltration, and the temporally associated microvascular events, by examining the effect of H1- and H2-receptor antagonist pretreatment. A combination of cimetidine and pyrilamine significantly reduced eosinophil accumulation, whereas neither antagonist alone was effective. Similarly, cutaneous hyperemia, measured indirectly as ear surface temperature, was reduced only by the cimetidine-pyrilamine combination. Pyrilamine partially attenuated the increase in microvascular permeability, but the addition of cimetidine provided no further reduction. It appears that histamine participates significantly in mediating both the microvascular changes and the eosinophil infiltration evoked by cutaneous anaphylaxis. The histaminergic component of increased microvascular permeability appears to be an H1-receptor mediated phenomenon. However, blockade of both H1- and H2-receptor subtypes is required to inhibit the hyperemia and eosinophil infiltration responses.
几种物质可改变嗜酸性粒细胞的运动，但这些假定的介质在速发型超敏反应中的相对重要性仍不清楚。本研究通过检测H1和H2受体拮抗剂预处理的效果，重新探讨了组胺在I型过敏性嗜酸性粒细胞浸润及与之相关的微血管事件中的作用。西咪替丁和吡苄明联合使用可显著减少嗜酸性粒细胞的聚集，而单独使用任何一种拮抗剂均无效。同样，以耳表面温度间接测量的皮肤充血，仅在西咪替丁和吡苄明联合使用时才会降低。吡苄明部分减弱了微血管通透性的增加，但加入西咪替丁后并未进一步降低。看来组胺在介导皮肤过敏反应引起的微血管变化和嗜酸性粒细胞浸润中均起重要作用。微血管通透性增加的组胺能成分似乎是一种由H1受体介导的现象。然而，需要同时阻断H1和H2受体亚型才能抑制充血和嗜酸性粒细胞浸润反应。
