Munck O, Madsen P V, Kelbaek H, Godtfredsen J
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark.
Clin Physiol. 1993 Jul;13(4):419-27. doi: 10.1111/j.1475-097x.1993.tb00341.x.
A slow washout of 201Thallium has a high diagnostic and prognostic value for coronary artery disease. The aim of the present work was to contribute with reference data on 201Tl uptake and washout from the myocardium. With a quantitative method using circumferential profiles and interpolative background subtraction we performed 201Tl myocardial imaging in two groups of subjects with a low probability of coronary artery disease. Washout in per cent is defined as (1-D/I).100, where D is the delayed uptake rate and I the initial uptake rate. In group A (n = 16) myocardial hyperaemia was induced by maximal exercise, in group B (n = 15) by intravenous infusion of dipyridamole. In group A, the mean washout was 52%, and in group B it was 34% (P < 0.001). The delayed uptake rate D was significantly higher after dipyridamole, 58.4 cps, than after exercise, 44.5 cps (P < 0.05). There was no significant differences in I between the two groups. The findings regarding D and I explain that the washout is slower after dipyridamole than after exercise, as the mean D/I ratio was 0.48 in group A and 0.66 in group B (P < 0.001).
铊-201缓慢洗脱对冠状动脉疾病具有较高的诊断和预后价值。本研究的目的是提供有关铊-201在心肌摄取和洗脱的参考数据。我们采用圆周轮廓定量法和内插背景减法，对两组冠状动脉疾病可能性较低的受试者进行了铊-201心肌显像。洗脱百分比定义为(1-D/I)×100，其中D为延迟摄取率，I为初始摄取率。A组（n = 16）通过最大运动诱发心肌充血，B组（n = 15）通过静脉输注双嘧达莫诱发。A组的平均洗脱率为52%，B组为34%（P < 0.001）。双嘧达莫后的延迟摄取率D显著高于运动后，分别为58.4 cps和44.5 cps（P < 0.05）。两组之间的I无显著差异。关于D和I的研究结果解释了双嘧达莫后的洗脱比运动后慢，因为A组的平均D/I比值为0.48，B组为0.66（P < 0.001）。
