Wüst J, Hardegger U
Department of Medical Microbiology, University of Zurich, Switzerland.
Chemotherapy. 1993 Sep-Oct;39(5):293-6. doi: 10.1159/000239139.
The concentrations of clarithromycin after a single oral dose of 500 mg were determined in serum and saliva of ten healthy adult volunteers. After 2 h, the levels were 4.04 +/- 1.14 (SD) mg/l in serum and 2.72 +/- 0.87 mg/l in saliva. After 7 h these values were 1.98 +/- 0.65 and 1.21 +/- 0.34 mg/l, respectively, and at the end of the dosing interval of 12 h, 0.95 +/- 0.38 and 0.73 +/- 0.35 mg/l, respectively. In comparison, amoxicillin (a 750-mg single dose) showed a much faster decline of serum levels and was virtually undetectable in saliva.
在10名健康成年志愿者的血清和唾液中测定了单次口服500毫克克拉霉素后的浓度。2小时后，血清浓度为4.04±1.14（标准差）毫克/升，唾液浓度为2.72±0.87毫克/升。7小时后，这些值分别为1.98±0.65和1.21±0.34毫克/升，在12小时给药间隔结束时，分别为0.95±0.38和0.73±0.35毫克/升。相比之下，阿莫西林（单次剂量750毫克）血清水平下降得更快，在唾液中几乎检测不到。
