Henningfield J E, Stapleton J M, Benowitz N L, Grayson R F, London E D
Addiction Research Center, National Institute on Drug Abuse, Balitmore, MD 21224.
Drug Alcohol Depend. 1993 Jun;33(1):23-9. doi: 10.1016/0376-8716(93)90030-t.
We examined differences between arterial and venous concentrations of nicotine in human subjects. Shortly after smoking a cigarette, levels of nicotine in arterial plasma were more than double those in venous plasma. The time course of the rise in arterial nicotine levels and the magnitude of the arteriovenous difference varied considerably among subjects. For some subjects, arterial nicotine concentrations after one cigarette were similar to venous concentrations typically observed after 20 cigarettes and were nearly 10 times greater than venous concentrations. Our findings have implications for understanding the high degree of addictiveness and cardiovascular toxicity of smoked forms of drugs.
我们研究了人体受试者动脉血和静脉血中尼古丁浓度的差异。吸烟后不久，动脉血浆中的尼古丁水平是静脉血浆中的两倍多。动脉尼古丁水平升高的时间进程以及动静脉差异的幅度在不同受试者之间有很大差异。对于一些受试者来说，吸一支烟后的动脉尼古丁浓度与通常吸20支烟后观察到的静脉浓度相似，且比静脉浓度高出近10倍。我们的研究结果对于理解吸烟形式毒品的高度成瘾性和心血管毒性具有重要意义。
