Hatsukami D K, Pickens R W, Svikis D S, Hughes J R
Department of Psychiatry, University of Minnesota 55455.
Addict Behav. 1988;13(1):91-5. doi: 10.1016/0306-4603(88)90031-7.
Frequency and durational components of smoking topography were measured by a portable smoking device while 10 subjects smoked four cigarettes ad libitum in a non-laboratory environment. Nicotine blood levels were measured before and after smoking each cigarette and serial blood samples for determining nicotine metabolic half-life were obtained the following day. Results showed that change in pre- and post-cigarette nicotine levels and metabolic half-life for nicotine were not related to within-cigarette topography measures or nicotine yield of cigarette, but were significantly related to intercigarette interval.
在非实验室环境中，10名受试者随意吸食4支香烟时，通过便携式吸烟装置测量吸烟行为的频率和持续时间成分。在每支香烟吸食前后测量尼古丁血药浓度，并在第二天采集系列血样以测定尼古丁代谢半衰期。结果显示，香烟吸食前后尼古丁水平的变化以及尼古丁的代谢半衰期与香烟内吸烟行为测量指标或香烟尼古丁产率无关，但与吸两支烟之间的间隔时间显著相关。
