Hirsch E, Maton B, Vergnes M, Depaulis A, Marescaux C
Service d'Epileptologie Clinique, Hôpitaux Universitaires de Strasbourg, France.
Epilepsy Res. 1993 Jun;15(2):133-9. doi: 10.1016/0920-1211(93)90093-m.
The behavioral and EEG concomitants of kindling produced by daily electrical stimulation of the inferior colliculus have been recorded in three series of Wistar rats: (1) non epileptic controls (NE), (2) rats susceptible to audiogenic seizures (AS), (3) acoustically susceptible rats with prior kindling of audiogenic seizures by repeated sound exposure (KAS). Repeated collicular stimulation produced behavioral and EEG changes which were similar in the AS and the NE rats. The tonic seizure without cortical discharges elicited by the first stimulation progressively changed into tonic-clonic seizures with sustained cortical EEG discharges after more than 20 stimulations. In the KAS group, the electrical collicular kindling was clearly accelerated: kindled tonic-clonic seizures and their EEG discharges already occurred after one to five electrical stimulations. Similarly, after completion of electrical collicular kindling in AS, sound stimulations immediately induced characteristic kindled audiogenic seizures. The immediate reciprocal positive transfer observed between kindling of audiogenic seizures and kindling of seizures induced by electrical stimulation of the inferior colliculus suggests that kindling of these two brain-stem seizures involves similar structures and mechanisms.
在三组Wistar大鼠中记录了通过每日电刺激下丘所产生的点燃效应的行为和脑电图伴随现象：（1）非癫痫对照组（NE），（2）对听源性癫痫敏感的大鼠（AS），（3）通过反复声音暴露预先点燃听源性癫痫的声学敏感大鼠（KAS）。反复的下丘刺激产生了行为和脑电图变化，这些变化在AS大鼠和NE大鼠中相似。首次刺激引发的无皮质放电的强直性癫痫在20多次刺激后逐渐转变为伴有持续皮质脑电图放电的强直阵挛性癫痫。在KAS组中，电刺激下丘的点燃效应明显加速：在一至五次电刺激后就已经出现点燃的强直阵挛性癫痫及其脑电图放电。同样，在AS大鼠完成电刺激下丘点燃后，声音刺激立即诱发典型的点燃听源性癫痫。在听源性癫痫的点燃和电刺激下丘诱发的癫痫的点燃之间立即观察到的相互正向转移表明，这两种脑干癫痫的点燃涉及相似的结构和机制。
