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[分子遗传学诊断在猪恶性高热综合征(MHS)选种中的应用]

[Use of molecular genetic diagnosis of malignant hyperthermic syndrome (MHS) in selection of pigs].

作者信息

Brém G, Brening B

出版信息

Genetika. 1993 Jun;29(6):1009-13.

PMID:8370496
Abstract

Recently, a mutation has been discovered in the ryanodine-receptor gene causing malignant hyperthermic syndrome (MHS) in pigs. Taking advantage of the RCR analysis of tissue samples from pigs of the Deutch Landeras breed we could have demonstrated that the gene-diagnostics MHS analysis is a simple, reliable and significant way of gene-typing for the stress resistance. Employing this test with sufficient reliability and effectively will make it possible to create homozygous stress resistant lines and to produce heterozygous stress resistant animals having both good meat quality tending to improvement and good feeding characters. The advantages of this first gene--technological technique just ready for application in animal breeding seem to ensure its quick implementation into the applied pig breeding.

摘要

最近,在兰尼碱受体基因中发现了一种突变,该突变会导致猪出现恶性高热综合征(MHS)。利用对德国兰德瑞斯猪组织样本的RCR分析,我们可以证明基因诊断MHS分析是一种用于抗应激能力基因分型的简单、可靠且重要的方法。以足够的可靠性和有效性应用此测试,将有可能培育出纯合抗应激品系,并培育出具有肉质改善趋势且饲养性状良好的杂合抗应激动物。这种刚准备好应用于动物育种的首个基因技术的优势,似乎确保了它能迅速应用于实际的猪育种中。

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