碳二亚胺介导的Z-脯氨酸-亮氨酸-羟基与苯并氮杂-15-冠-5的模型偶联研究。
Studies on the carbodiimide-mediated model couplings of Z-Pro-Leu-OH with benzoaza-15-crown-5.
作者信息
Kulikov N V, Basok S S, Lukyanenko N G
机构信息
A.V. Bogatsky Physico-Chemical Institute, Ukrainian Academy of Sciences, Odessa.
出版信息
Int J Pept Protein Res. 1993 Jul;42(1):20-3. doi: 10.1111/j.1399-3011.1993.tb00344.x.
Abstract
A series of model DCC-mediated couplings of Z-Pro-D-Leu-OH with 2,3-benzo-10-aza-1,4,7,13-tetraoxacyclopentadeca-2-ene were studied by high-performance liquid chromatography. It was found that racemization during preparation of N-(Z-Pro-Leu-)benzoaza-15-crown-5 is promoted by HOBT, an additive usually reducing this process.
摘要
通过高效液相色谱法研究了一系列Z-脯氨酸-D-亮氨酸-OH与2,3-苯并-10-氮杂-1,4,7,13-四氧杂环十五碳-2-烯的DCC介导的偶联反应。结果发现，在制备N-（Z-脯氨酸-亮氨酸-）苯并氮杂-15-冠-5的过程中，通常会减少外消旋化过程的添加剂HOBT反而促进了外消旋化。
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