非保护二肽的序列选择性视觉识别

Sequence-selective visual recognition of nonprotected dipeptides.

作者信息

Tsubaki Kazunori, Kusumoto Tomokazu, Hayashi Noriyuki, Nuruzzaman Mohammad, Fuji Kaoru

机构信息

Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.

出版信息

Org Lett. 2002 Jul 11;4(14):2313-6. doi: 10.1021/ol026191n.

DOI:10.1021/ol026191n

PMID:12098235

Abstract

[structure: see text] A receptor 1 with phenolphthalein and two crown ethers in the molecule develops brilliant purple color in the presence of dipeptides with a specific amino acid-sequence containing a C-terminal lysine. This type of color development could be extended to the detection of oligopeptides of a specific sequence at the N-terminal such as scyliorhinin I and APP(770)(394-410).

摘要

[结构：见文本] 分子中含有酚酞和两种冠醚的受体1在存在含有C端赖氨酸的特定氨基酸序列的二肽时会呈现出亮紫色。这种显色类型可以扩展到检测N端特定序列的寡肽，如猫鲨素I和APP(770)(394 - 410)。