Portaluppi F, Vergnani L, Margutti A, Ambrosio M R, Bondanelli M, Trasforini G, Rossi R, Degli Uberti E C
Endocrinology Section, Chair of Internal Medicine, University of Ferrara, Italy.
J Clin Endocrinol Metab. 1993 Sep;77(3):816-20. doi: 10.1210/jcem.77.3.8370703.
Calcitonin gene-related peptide (CGRP) has positive chronotropic and inotropic effects in animals and humans, and produces the most potent vasodilation known for an endogenous peptide. Yet, a physiological role for CGRP in the regulation of vascular tone and blood pressure has not been demonstrated. We studied the effects of 1) assumption of the upright position and 2) iv infusion of angiotensin-II (sequential doses of 8, 16, and 32 ng/kg.min, each dose for 20 min) in eight normal subjects (four men). Serial venous blood samples were taken to determine the plasma CGRP, epinephrine, norepinephrine, and aldosterone levels and PRA. Blood pressure and heart rate were continuously monitored at the finger with a Finapres 2300 instrument. After assumption of the upright posture, a quick rise in plasma CGRP levels was observed together with the expected increases in plasma norepinephrine and aldosterone and PRA. A transient increment was also observed for diastolic blood pressure and heart rate. Angiotensin-II infusion caused dose-dependent increases in plasma CGRP and aldosterone concentrations, already significant at the lowest infusion rate and parallel with the blood pressure rise. Plasma catecholamines significantly increased only at higher infusion rates. Our data demonstrate that modifications of plasma CGRP concentrations are part of the normal response to postural and vasomotor changes. These findings suggest a physiological role for CGRP in regulation of the peripheral vascular tone and possibly blood pressure in man.
降钙素基因相关肽（CGRP）在动物和人类中具有正性变时和变力作用，并能产生已知内源性肽中最强的血管舒张作用。然而，CGRP在调节血管张力和血压方面的生理作用尚未得到证实。我们研究了8名正常受试者（4名男性）在1）站立位和2）静脉输注血管紧张素II（依次给予8、16和32 ng/kg·min的剂量，每个剂量持续20分钟）时的效应。采集系列静脉血样以测定血浆CGRP、肾上腺素、去甲肾上腺素、醛固酮水平及肾素活性（PRA）。使用Finapres 2300仪器持续监测手指处的血压和心率。站立位后，观察到血浆CGRP水平迅速升高，同时血浆去甲肾上腺素、醛固酮及PRA出现预期的升高。舒张压和心率也出现短暂升高。输注血管紧张素II导致血浆CGRP和醛固酮浓度呈剂量依赖性增加，在最低输注速率时即已显著增加，且与血压升高平行。仅在较高输注速率时血浆儿茶酚胺才显著增加。我们的数据表明，血浆CGRP浓度的改变是对体位和血管舒缩变化的正常反应的一部分。这些发现提示CGRP在调节人类外周血管张力及可能的血压方面具有生理作用。
